Abstract
This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of <i>Anacardium occidentale</i> methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of <i>Anacardium occidentale</i> nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of <i>Anacardium occidentale</i> nut extract significantly decreased (p<0.05) the fasting blood glucose level, oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) concentrations and significantly increase (p<0.05) the high-density lipoprotein (HDL) in diabetic treated rats. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Reduced glutathione (GSH), and Catalase (CAT) levels significantly (p<0.05) increases with a decrease Malondialdehyde (MDA) level in diabetic treated rats. Food intake and bodyweight of diabetic treated rats significantly increases (p<0.05). Markers of liver and kidney functions were also improved in diabetic treated rats. The results from this study suggest that <i>Anacardium occidentale</i> nut may be useful in the therapeutic management of diabetes and its related complications.
Highlights
Diabetes mellitus is a cluster of metabolic diseases characterized by hyperglycemia as a result of abnormal secretion and action of insulin or both
Chronic hyperglycemia leads to long-term diabetic complications such as macrovascular and microvascular disease, dyslipidemia, and oxidative stress [3]
Long-term hyperglycemia in diabetes mellitus generates reactive oxygen species (ROS), and a decline in antioxidant status which destroys the cells with resultant secondary complications [5]
Summary
Diabetes mellitus is a cluster of metabolic diseases characterized by hyperglycemia as a result of abnormal secretion and action of insulin or both. Chronic hyperglycemia leads to long-term diabetic complications such as macrovascular and microvascular disease, dyslipidemia, and oxidative stress [3]. Long-term hyperglycemia in diabetes mellitus generates reactive oxygen species (ROS), and a decline in antioxidant status which destroys the cells with resultant secondary complications [5]. This elevation in the ROS level could be due to a decrease in destruction and/or increase in catalase
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
