Abstract
In perfused rat liver, hyperosmolarity induces Fyn-mediated Mrp2-/Bsep-retrieval from the canalicular membrane (Cantore et al., JBC 2011) leading to cholestasis. Cyclic AMP and TUDC induce choleresis by the increase of Na+-taurocholate cotransport via Ntcp-insertion to hepatocyte basolateral plasma membranes. The aim of the study was to elucidate the underlying signaling events.
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