Abstract
Introduction: The changing microbial environment, Darwinian medicine and the hygiene hypothesis.- The paleolithic disease-scape, the hygiene hypothesis, and the second epidemiological transition.- Immunoregulation by microbes and parasites in the control of allergy and autoimmunity.- Hepatitis A virus, TIM-1 and allergy.- Linking lifestyle with microbiota and risk of chronic inflammatory disorders.- Soil bacteria, nitrite and the skin.- The hygiene hypothesis and allergic disorders.- Multiple sclerosis.- Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths.- The hygiene hypothesis and Type 1 diabetes.- The hygiene hypothesis and affective and anxiety disorders.- Immune regulation in atherosclerosis and the hygiene hypothesis.- The 'delayed infection' (aka 'hygiene') hypothesis for childhood leukaemia.- Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis?.- Alternative and additional mechanisms to the hygiene hypothesis.
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