Abstract
A solution of 30% aqueous H 2O 2 in trifluoroacetic acid converts linear alkanes and cycloalkanes to an equilibrium mixture of secondary alcohols and their trifluoroacetates. There is no trace of further oxidation to ketones. Yields and conversions can be 70–90%, but are limited by elimination and epoxidation to form vicinal glycols. Linear alkyl chains are also hydroxylated in good yields with selectivity for introducing the alcohol group remote from electronegative substituents. The active reagent is trifluoroperoxyacetic acid, and it is effective in the presence of 4–10% water. When tertiary hydrogens are present, the oxidations are more complex.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
