Abstract
The global Human Proteome Project (HPP) was announced by the Human Proteome Organization (HUPO) at the 2010 World Congress of Proteomics in Sydney, Australia, and launched at the 2011 World Congress of Proteomics in Geneva, Switzerland, with analogies to the highly successful Human Genome Project. Extensive progress was reported at the September 2012 World Congress in Boston, USA. The HPP is designed to map the entire human proteome using available and emerging technologies.The HPP aims to create a molecular and biological foundation for improving health globally through better understanding of disease processes, more accurate diagnoses, and targets for more effective therapies and preventive interventions against many diseases. There are opportunities for individual investigators everywhere to access advanced datasets and to join HPP research teams.
Highlights
As described at BioVision 2012 at the Bibliotheca Alexandrina in Alexandria, Egypt, in April 2012, the Human Genome Project has dramatically increased knowledge of inherited diseases and the genetic contribution to all kinds of complex diseases.[1]
One of the big surprises of the Human Genome Project was the number of protein-coding genes
While there are exactly two copies of nearly every gene in every nucleated cell of the 230 cell types of the body, the number of copies of a protein may vary enormously over time, in different organs and body fluids, and from protein to protein. This Project will be important to Global Health since proteins are the molecular targets of most pharmaceuticals and are used in medicine and public health for diagnosis and for vaccines
Summary
As described at BioVision 2012 at the Bibliotheca Alexandrina in Alexandria, Egypt, in April 2012, the Human Genome Project has dramatically increased knowledge of inherited diseases and the genetic contribution to all kinds of complex diseases.[1] The biological and clinical progress in genomics made feasible remarkable advances in technologies for sequencing and synthesizing nucleic acids and proteins and for manipulating genes and regulation of gene expression. The foundation for the Project lies in major knowledge bases with systematically organized data about proteins generated from mass spectrometry and from antibody-capture approaches. One of the big surprises of the Human Genome Project was the number of protein-coding genes. This journal is published by the University Library System of the University of Pittsburgh as part of its D-Scribe Digital Publishing Program, and is cosponsored by the University of Pittsburgh Press
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