The Humoral Response of Mouse Spleen Cells to Two Types of Sheep Erythrocytes. IV. the in Vivo Response to H and L Srbc and the Genetic Control of the Production of IgM and IgG Antibodies in Discriminator Mice

Abstract

Abstract It has been shown previously that the in vitro response of mouse spleen cells to two types of sheep erythrocytes (high-H SRBC; low- L SRBC)2 is under multi-gene control (1). We have concluded that there are common or shared antigen(s) (C) found on both types of SRBC and extra antigen(s) (E) unique to H SRBC. The responses of spleen cell suspensions from various strains of mice to H SRBC have been divided into three categories: non-discriminator (ND), low-discriminator (LD), and high-discriminator (HD) based on the ratios of the number of plaque-forming cells (PFC) seen with H and L SRBC when the response is assayed after 4 days of culture (1). Only LD and HD mice are able to respond to the extra antigens on H SRBC. The in vitro response of discriminator mice to the C antigens is normal in LD and low in HD mice. This concept is illustrated in Table I.