Abstract
Experiments based on enzyme-linked immunosorbent assay (ELISA) revealed considerable antigenic homology in turbot between two species of microsporidian, Tetramicra brevifilum (a parasite of the turbot, Scophthalmus maximus) and Glugea caulleryi (a parasite of the lesser sand-eel, Ammodytes tobianus). We next investigated whether G. caulleryi is able to suppress the turbot immune response. Intraperitoneal inoculation of turbot with G. caulleryi spores (whether heat-killed or viable) did not suppress the humoral immune response to injection of G. caulleryi spores plus adjuvant 15 days later; in fact, specific serum antibody levels (as revealed by ELISA) reached maximum levels by about Day 30 post re-exposure. Similar results were obtained with cellular enzyme-linked immunosorbent assay: 15 days after injection with G. caulleryi spores plus adjuvant, specific antibody secretion rate was higher in turbot which had been pre-exposed to G. caulleryi spores than in turbot which had not been pre-exposed.
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