Abstract
The human T-cell receptor γ (TRG) chain genes, like those encoding the T-cell receptor α- and β-polypeptides, undergo rearrangements specifically in T cells. The human TRG locus, which has been completely mapped, is composed of two constant region genes (TRGC), five joining segments (TRGJ) and at least 14 variable γ-genes (TRGV). Eight variable genes are functional and belong to four different subgroups. The product of the rearranged TRG gene is the γ-chain which is expressed, along with the δ-chain, at the surface of a subset of T lymphocytes. Although some γδ + cells display a cytolytic activity, their precise function remains to be elucidated.
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