Abstract
ABSTRACT The prostate glands of 8 anencephalic monsters and 36 controls have been examined particularly with regard to metaplastic changes which occur in response to oestrogenic stimulation during pregnancy. Although oestriol levels in mothers of such monsters have been reported to be low, it was noted that with one exception, these organs showed marked and, in some instances, extreme metaplastic changes, sometimes even surpassing the appearances in normal controls. In contrast to the above findings there was a diminished proliferation of glands noted in the majority of cases. There was also diminished glandular secretion or no secretion whatsoever. The significance of these findings has been discussed.
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