Abstract
Proteomics has opened up new avenues in the field of gynecology in the post-genome era, making it possible to meet patient needs more effectively and improve their care. This mini-review aims to reveal the scope of proteomic applications through an overview of the technique and its applications in assisted procreation. Some of the latest technologies in this field are described in order to better understand the perspectives of its clinical applications. Proteomics seems destined for a promising future in gynecology, more particularly in relation to the ovary. Nevertheless, we know that reproductive biology proteomics is still in its infancy and major technical and ethical challenges must first be overcome.
Highlights
Proteomics is an emerging discipline that involves studying the proteome, namely the gene expression of a cell, tissue or organism, through analyzing proteins and their subsequent translational modifications by mass spectrometry (MS)
This study demonstrated that overexpression of glutathione S-transferase A4 (GSTA4) is implicated in protecting cells against apoptosis, while overexpression of glutathione S-transferase P (GSTP) may be associated with the c-Jun N-terminal kinase signaling pathway (JNK), shielding cells from death signals or oxidative stress [6]
The results of this study suggest that proteins identified in cumulus cells may play a role in folliculogenesis, and in the immune response
Summary
Proteomics is an emerging discipline that involves studying the proteome, namely the gene expression of a cell, tissue or organism, through analyzing proteins and their subsequent translational modifications by mass spectrometry (MS). MS analysis is performed on individual peptides, and data are merged and consolidated to reveal the protein identity and/or its characteristics [1]. This automated process is greatly facilitated by the use of well-annotated proteome databases and bioinformatics (Figure 1). Genomics provides valuable information on certain biological functions, the proteome is the complete representation of proteins expressed by a genome. It is more representative of the phenotype and able to provide complementary information that is yielded by gene expression studies.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
