Abstract

1993). Since undifferentiated keratinocytes (i.e. basal cells) provide the major supply of catecholamines to the total epidermis, it seems feasible that those basal cells in contact with melanocytes are of major importance in signal transduction, metabolism, growth and differentiation. Any local trauma to the epidermis by infection or physical damage can attract infiltrating lymphocytes to produce the biological ‘oxygen-burst’ leading to a local release of superoxide anion radicals

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