Abstract
Thrombin-mediated platelet function is enhanced by the presence of C3, C5, C6, C7, C8 and C9 of human complement. The interaction of thrombin with its receptor on the platelet membrane initiates activation of complement on the platelet surface. Trypsin mediated platelet function is not enhanced by the addition of complement, probably since trypsin has no receptor on the platelet surface so activation of complement is triggered in the fluid phase and not on the platelet surface. Activation of complement by thrombin led to production of C5-9 complexes on the platelet surface. These complexes were eluted from the platelet membrane and were identified physicochemically and morphologically.The mechanism of the complement induced enhancement of platelet function is not clear, however It is mediated via the arachidonic acid transformation pathway since this activity wos Inhibited by known inhibitors of cycla-oxygenase namely aspirin and indomethacin.
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