Abstract
The host cell side of latent HIV-1 infection.
Highlights
The ability of HIV-1 to establish an extremely stable latent viral reservoir in the CD4+ memory T cell population prevents viral eradication with the currently available antiretroviral drugs
The fact that latent HIV-1 infection has mostly been described in the memory T cell population, which forms part of our lifelong immunity against pathogens, seems to justify the extraordinary stability of the viral reservoir
No matter the exact nature of host cells of the latent HIV-1 reservoir, under the assumption that latent HIV-1 infection events are established in functional memory T cells, we should observe continuous and complete contraction of the reservoir as these T cells encounter their cognate antigen over time, as a cognate antigen induced recall response should trigger HIV1 reactivation
Summary
The ability of HIV-1 to establish an extremely stable latent viral reservoir in the CD4+ memory T cell population prevents viral eradication with the currently available antiretroviral drugs. The fact that latent HIV-1 infection has mostly been described in the memory T cell population, which forms part of our lifelong immunity against pathogens, seems to justify the extraordinary stability of the viral reservoir.
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