Abstract
Background Why and when the immune system provokes TH2 mediated allergic immune responses is still not well understood. Dendritic cells are one of the master regulators during the induction of allergic airway inflammation providing stimuli for TH2 cell differentiation. Most of the major as well as minor mammalian allergens causing respiratory sensitization belong to the lipocalin family. We investigated two homologous lipocalins, the endogenous non-allergenic human Lcn-1 and the major respiratory dog allergen Can f 1 to study their effects on human monocyte derived dendritic cells in order to initiate allergic immune responses.
Highlights
Why and when the immune system provokes TH2 mediated allergic immune responses is still not well understood
We investigated two homologous lipocalins, the endogenous non-allergenic human Lcn-1 and the major respiratory dog allergen Can f 1 to study their effects on human monocyte derived dendritic cells in order to initiate allergic immune responses
We found that the homologous lipocalins had differential effects on dendritic cells depending on their allergenic potential
Summary
Why and when the immune system provokes TH2 mediated allergic immune responses is still not well understood. Dendritic cells are one of the master regulators during the induction of allergic airway inflammation providing stimuli for TH2 cell differentiation. Most of the major as well as minor mammalian allergens causing respiratory sensitization belong to the lipocalin family. We investigated two homologous lipocalins, the endogenous non-allergenic human Lcn-1 and the major respiratory dog allergen Can f 1 to study their effects on human monocyte derived dendritic cells in order to initiate allergic immune responses
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
