Abstract
BackgroundThe global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South America. Phylogenetic studies indicate that subtype C viruses were introduced to South America through a single founder event that occurred in Southern Brazil. However, the external route via which subtype C viruses spread to the South American continent has remained unclear.Methodology/Principal FindingsWe used automated genotyping to screen 8,309 HIV-1 subtype C pol gene sequences sampled within the UK for isolates genetically linked to the subtype C epidemic in South America. Maximum likelihood and Bayesian approaches were used to explore the phylogenetic relationships between 54 sequences identified in this screen, and a set of globally sampled subtype C reference sequences. Phylogenetic trees disclosed a robustly supported relationship between sequences from Brazil, the UK and East Africa. A monophyletic cluster comprised exclusively of sequences from the UK and Brazil was identified and dated to approximately the early 1980s using a Bayesian coalescent-based method. A sub-cluster of 27 sequences isolated from homosexual men of UK origin was also identified and dated to the early 1990s.ConclusionsPhylogenetic, demographic and temporal data support the conclusion that the UK was a crucial staging post in the spread of subtype C from East Africa to South America. This unexpected finding demonstrates the role of diffuse international networks in the global spread of HIV-1 infection, and the utility of globally sampled viral sequence data in revealing these networks. Additionally, we show that subtype C viruses are spreading within the UK amongst men who have sex with men.
Highlights
Founder effects, genetic drift and recombination associated with the global spread of HIV-1 infection have given rise to genetically distinct viral strains referred to as ‘subtypes’ and ‘circulating recombinant forms’ [1]
Phylogenetic, demographic and temporal data support the conclusion that the United Kingdom (UK) was a crucial staging post in the spread of subtype C from East Africa to South America
We show that subtype C viruses are spreading within the UK amongst men who have sex with men
Summary
Genetic drift and recombination associated with the global spread of HIV-1 infection have given rise to genetically distinct viral strains referred to as ‘subtypes’ and ‘circulating recombinant forms’ [1]. Of the various HIV-1 strains that have been described, the most prevalent worldwide is subtype C [3]. First described in East and Southern Africa [4], infections with viruses belonging to (or partially derived from) subtype C are prevalent in regions throughout the world, including India, China, and South America [3,5,6]. The global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South America. Phylogenetic studies indicate that subtype C viruses were introduced to South America through a single founder event that occurred in Southern Brazil. The external route via which subtype C viruses spread to the South American continent has remained unclear
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