Abstract

The human immunodeficiency virus (HIV) is associated with one of the most widespread infectious disease, the acquired immunodeficiency syndrome (AIDS). The development of antiretroviral drugs and methods for virus detection requires a comprehensive analysis of the HIV genomic diversity, particularly in the binding sites of oligonucleotides. Here, we describe a versatile online database (HIVoligoDB) with oligonucleotides selected for the diagnosis of HIV and treatment of AIDS. Currently, the database provides an interface for visualization, analysis and download of 380 HIV-1 and 65 HIV-2 oligonucleotides annotated according to curated reference genomes. The database also allows the selection of the most conserved HIV genomic regions for the development of molecular diagnostic assays and sequence-based candidate therapeutics. Database URL: http://portugene.com/HIVoligoDB

Highlights

  • The human immunodeficiency virus (HIV) is a significant threat to public health, being associated with the acquired immunodeficiency syndrome (AIDS), one of the most widespread infectious diseases at global scale [1]

  • HIV-1 is responsible for most cases of AIDS while HIV-2 is confined mainly to West Africa, several HIV-2 infections can be found in Mozambique, Angola, France and Portugal [2]

  • The HIVoligoDB is a free resource with detailed records of oligonucleotides to study HIV-1 and HIV-2

Read more

Summary

Introduction

The human immunodeficiency virus (HIV) is a significant threat to public health, being associated with the acquired immunodeficiency syndrome (AIDS), one of the most widespread infectious diseases at global scale [1]. Some databases include genomic information for HIV-1 and HIV-2 (see online supplementary material for Figure S1). The NCBI Probe Database (https://www.ncbi.nlm.nih.gov/probe) includes oligonucleotides for HIV, but lack any data on sequence conservation.

Results
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.