The histopathological changes comparison in healthy rabbit lung ventilated with ZEEP, Sigh and PEEP

Ç Yardimci,I Paksoy,G Meyanci,H Öz

doi:10.1186/cc1097

Abstract

Our aim was to compare the effects of LV + ZEEP, LV + Sigh and LV + PEEP on histopathological changes with healthy rabbit lungs. Fifteen New Zeland rabbits were randomly divided into three groups (n = 5). Animals were ventilated for 3 hours with FiO2:1.0, f:80/dk. Group1: Low volume (5 ml/kg) + ZEEP, Group 2: Low volume (5 ml/kg) + 10 cmH2O PEEP, Group 3: Low volume (5 ml/kg) + Sigh. At the end of 3 hours the animals were sacrificed for histopathological evalotion. Lungs were removed and fixed in 10% buffered formaldehyde. Tissue sections were processed in the usual manner for light microscopic examination with Hematoxylin–Eosin stain. The pathological lesions were classified ranging from 0 to ++++. There were statistically significant differences between ZEEP and PEEP groups, ZEEP and Sigh groups (P < 0.05). The damage were prominent in the ZEEP group for alveolar hemorrhage and congestion. There were no statistically significance within groups for notrofill infiltration and density. But the damage were more significant than the others in the ZEEP group. We saw atelectasia only in the Sigh group. The damage was more significant than the others in the ZEEP group. The atelectasia was seen only in the Sigh group. We conclude that adding Sigh and PEEP to low volume may decrease the damage and PEEP may be more effective to prevent atelectasia.

Highlights

In our experience, very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient
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Summary

Introduction

Very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient. There is evidence that increasing the dose of continuous renal replacement therapy (CRRT) is associated with improved survival in critically ill patients with acute renal failure (ARF) [1]. The aim of this study is to investigate if there is any difference in patients’ characteristics in ICU between COPD and nonCOPD diseases caused chronic respiratory failure and require mechanical ventilation during acute exacerbations. Noninvasive positive pressure ventilation (NPPV) has been reported to be beneficial in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD), and to facilitate weaning In this trial we assessed the possible benefit of early NPPV in patients with blunt chest trauma and acute respiratory failure. The aim of this study was to compare the pharmacokinetic and pharmacodynamic parameters and the clinical efficacy of a continuous infusion of cefepime versus an intermittent regimen in critically ill adults patients with gram negative bacilli infection. The purpose of the study is to identify the factors associated with DNR status in our institution

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