The histopathological and phenotypic characteristics of keloid and hypertrophic scar during wound closure with compressive and non-compressive sutures

Abstract

Keloids and hypertrophic scars are fibroproliferative disorders caused by abnormal wound healing. They extend beyond the borders of the primary wound, do not regress spontaneously, and tend to recur after excision. Every year in developed countries, about 100 million people face problems related to scars. Hypertrophied scars and keloids have a significant impact on the patient's quality of life, physical condition and psychological health. Compression sutures are traditionally used for wound closure in clinical practice. Compression sutures mean regular sutures, which are used to close the wound with a knotted suture, which causes tissue compression. Non-compressive sutures are sutures of ordinary composition treated with a unique technology, which have a tufted structure, and at the expense of these tufts, they close the wound without forming knots. In case of their use, the histopathological and phenotypic features of the development of keloids and skin scars compared to compressive threads require more research. In histopathological practice, the histopathological indicators that will allow us to determine the high and low risk groups for the development of keloids and hypertrophic scars are still not well studied; Which may have a great clinical value because it allowed us to identify the high and low risk of possible development of keloid based on Punch-biopsy. The complex mechanisms of keloid formation are still unknown and probably depend on the body's ability to respond to damage on the one hand and environmental factors, including the use of compression threads, on the other hand.