Abstract
Chromatin-immunoprecipitation and computational analysis implicate Rpd3p as an important co-factor in the network of genes regulating the yeast environmental stress response.
Highlights
Yeast responding to stress activate a large gene expression program called the Environmental Stress Response that consists of approximately 600 repressed genes and approximately 300 induced genes
Rpd3S is here we show that Rpd3p is required for proper initiation of the Environmental Stress Response (ESR), including normal regulation of both induced and repressed genes, in yeast responding to multiple stresses
Rpd3p is required for the full dynamic range of stressactivated gene expression changes We followed genomic expression in wild-type and rpd3Δ cells responding over time to a 25°C to 37°C heat shock, 0.4 mM H2O2, and 0.75 M NaCl
Summary
Yeast responding to stress activate a large gene expression program called the Environmental Stress Response that consists of approximately 600 repressed genes and approximately 300 induced genes. Sudden environmental changes can trigger rapid and dramatic changes in genomic expression This involves coordinated expression of hundreds to thousands of genes, whose expression is precisely modulated in timing and magnitude. Yeast respond to stress in part by initiating the Environmental Stress Response (ESR), which consists of approximately 600 genes whose expression is repressed and approximately 300 genes whose expression is induced by diverse stresses [1,2]. The repressed genes include approximately 130 ribosomal protein ('RP') genes and a distinct group of approximately 450 genes more broadly related to protein synthesis ('PS genes') Both groups are highly expressed in actively growing cells but sharply repressed, with slightly different expression profiles, in response to stress. Initiation of the ESR is not required to survive the offending stress but rather helps to protect cells against subsequent severe doses of the same or different stress ( it cannot fully explain acquired stress resistance in all cases) [3]
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