Abstract
The Histology and Histogenesis of Pulmonary Adenomata of Mice
Highlights
The alternative suggestion of alveolar epithelium necessitates presumptions of a much more far-reaching character, e.g. the actual existence in the fully developed lung of such a tissue is denied by many authorities, and some of those who claim to find it describe morphological appearances very different from those found in the tumour cells
If the alveolar epithelium is implicated, it can only be by reversion to the embryonic type, and if this occurs, such epithelium might owe its genesis, as it does in the embryo, to the bronchial epithelium
The present author's observations have convinced him that these tumours invariably originate in foci of chronic collapse inflammation, which become invaded by bronrchial epithelium, and that it is the extent of the original inflammatory focus which determines that of the formed adenoma
Summary
433 . 191 pre-adenomatous types which will later be described. It was noted, as was to be expected, that CBA mice are relatively resistant to the induction of pulmonary adenoma, whereas Strong "A," and to a somewhat lesser degree "White Label ", mice are highly susceptible. The amount of elastin may vary in different parts of the same tumour, and it has the appearance of being derived from the original alveolar framework, the parts of greatest density corresponding with collapse and fusion of alveolar walls (Fig. 3) These are the papillary cystadenomata of Tyzzer. The tumour cells of this type are generally somewhat larger than those of the tubulo-papillary type Both types of tumour are lepidic in structure, and presumably epithelial in nature, as it is sometimes difficult to draw any morphological distinction between flattened tumour cells and the vascular endothelium of the stroma there has never been any evidence of angiomatous structure.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
