Abstract
Urothelial carcinomas (UC) are likely to have particular morphological features that distinguish them from the typical form. These original aspects are called “histological variants of urothelial carcinoma”. They can constitute all or part of the tumor and concern mainly muscle invasive UC and high grade. Their frequency varies according to the type, but the knowledge of these variants is essential because of the diagnostic difficulties, and the implication of their presence on the prognosis.
Highlights
We present the different epidemiological, clinical, histological, prognostic and therapeutic aspects of each histological variant of urothelial carcinoma
In 1979, STERN described a variant of urothelial carcinoma with nests contiguous to each other [25]
The diagnosis of malignancy is based on the presence of cytonuclear atypia and/or the infiltrative nature of the lesion and/or the existence of a more typical urothelial carcinoma contingent
Summary
Open Access that distinguish them from the typical form. These original aspects are called “histological variants of urothelial carcinoma”. They can constitute all or part of the tumor and concern mainly the muscle-invasive and high grade UC [1]. Their frequency is variable depending on the type (some variants are very exceptional). We present the different epidemiological, clinical, histological, prognostic and therapeutic aspects of each histological variant of urothelial carcinoma
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