Abstract
Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders.
Highlights
Neuropsychiatric disorders are a group of multifaceted diseases characterized by cognitive deficits, mental health symptoms and somatoform symptoms, including schizophrenia, depression, Alzheimer’s disease, Parkinson’s disease, etc
The later extensive investigations discovered that histamine in the brain mediates diverse higher functions, including arousal, cognition and feeding, and have indicated the abnormalities in the histaminergic nervous system are closely related to neuropsychiatric disorders, including narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease
This review mainly introduces preclinical and clinical studies exploring the potential role of histaminergic system in neuropsychiatric disorders, including narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease
Summary
Neuropsychiatric disorders are a group of multifaceted diseases characterized by cognitive deficits, mental health symptoms and somatoform symptoms, including schizophrenia, depression, Alzheimer’s disease, Parkinson’s disease, etc. Neuropsychiatric disorders are chronic diseases beginning early in life and affecting patients across all age groups [1]. These conditions are a major public health challenge with highly prevalence, diminishing quality of life for millions of patients and their caregivers [2,3,4]. The later extensive investigations discovered that histamine in the brain mediates diverse higher functions, including arousal, cognition and feeding, and have indicated the abnormalities in the histaminergic nervous system are closely related to neuropsychiatric disorders, including narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease.
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