Abstract

In a series of thirty-eight patients who had various types of hepatic disease, the results of the hippuric acid test for hepatic function were studied in an attempt to correlate the results of such generally used procedures as the bromsulphalein test and those of the galactose test. The results seem to indicate that the rate of synthesis of hippuric acid is a reasonably accurate and satisfactory test for the determination of parenchymatous hepatic damage, particularly in the “surgical” types of jaundice. The errors noted are no greater than are those to which other hepatic functional tests are subject. From a physiologic standpoint, these results are of interest, since they add to the accumulated evidence which indicates that hepatic lesions have a definite influence on the rate of synthesis of hippuric acid in human beings.

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