Abstract
It is shown that dissolution of a soluble drug in high concentration from an insoluble matrix follows the Higuchi square root equation, except an initial lag phase and a terminal diffusion phase exist. The parameters (φ) involved in these correspond to one another. The diffusional cross-sectional area is an almost linear function with time. The slopes obtained from square root plots are in reasonable agreement with theoretical values, and the diffusion coefficient for the terminal phase correlates with the actual diffusion coefficient of the drug used (diphenhydramine hydrochloride).
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