The highly sensitive determination of serotonin by using gold nanoparticles (Au NPs) with a localized surface plasmon resonance (LSPR) absorption wavelength in the visible region.

Phuong Que Tran Do,Thang Bach Phan,Vu Thi Huong,Heongkyu Ju,Nguyen Tran Truc Phuong,Viet-Duc Phung,Nhu Hoa Thi Tran,Thi-Hiep Nguyen,Hanh Kieu Thi Ta,Kieu The Loan Trinh

doi:10.1039/d0ra05271j

Phuong Que Tran Do, Thang Bach Phan + Show 8 more

Open Access

https://doi.org/10.1039/d0ra05271j

Copy DOI

Abstract

The development of improved methods for the synthesis of monodisperse gold nanoparticles (Au NPs) is of high priority because they can be used as substrates for surface-enhanced Raman scattering (SERS) applications relating to biological lipids. Herein, Au NPs have been successfully synthesized via a seed-mediated growth method. The LSPR peak is controlled via adjusting the gold nanoseed component, and different fabrication methods were studied to establish the effect of sonication time on NP size. The simple, facile, and room-temperature method is based on a conventional ultrasonic bath, which leads to ultrasonic energy effects on the size and morphology of the Au NPs. This research offers new opportunities for the production of highly monodispersed spherical Au NPs without the use of a magnetic stirrer method, as evidenced by ultraviolet-visible reflectance spectra and scanning electron microscopy (SEM) analysis. SEM images indicate that the spherical Au NP colloidal particles are stable and reliable, which paves the way for their use as a nanostructured biosensor platform that can be exploited for multiple applications, for example, in materials science, sensing, catalysis, medicine, food safety, biomedicine, etc. The highest enhancement factor that could be achieved in terms of the SERS enhancement activity of these Au NP arrays was determined using 10−9 M serotonin (5-hydroxytryptamine, 5-HT) as the Raman probe molecules.

Highlights

Plasmonics is a term that relates to the localization and manipulation of an electromagnetic wave that propagates along a metal–dielectric interface
The time-dependent LSPR extinction in synthesized Au NP solutions was studied via UV-vis spectra, Paper exhibiting characteristic bands centered at 527.6 nm
LSPR can be tailored via designing plasmon-enhanced nanostructures with different sizes and shapes, and adjusting the components of the materials provides a great opportunity to develop clinical lab applications and tremendous ultra-sensitive chemical and biological sensors

Summary

Introduction

Plasmonics is a term that relates to the localization and manipulation of an electromagnetic wave that propagates along a metal–dielectric interface. The most attractive property of metal NPs is electromagnetic resonance based on the collective oscillation of free electrons, which results in localized surface plasmons (LSPs). There are two kinds of models of plasmonic nanostructures: (1) localized surface plasmons (LSPs) and (2) propagating surface plasmons (PSPs). With LSPs, the oscillation can be in resonance with the incident light at a speci c excitation frequency (w), resulting in the strong oscillation of the surface electrons, which is called a localized surface plasmon resonance (LSPR) mode.[2] In recent years, LSPR sensors based on metal nanostructures or nanoparticles have generated increasing interest.[3] In contrast to propagating SPR, LSPR sensors can be fabricated via immobilizing metalized nanostructured materials on a substrate (clean glass, optical ber, etc.).[4] Recently, the decoration of plasmonic

Methods

Results

Conclusion