The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas.

Rongzhong Jin,Tiancheng Zhang,Caihua Liao,Sijing Li,Hailin Ma,Zhaoxia Yu,Jia Shen,Qiliang Liu

doi:10.18632/oncotarget.17345

Abstract

BackgroundInvasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets.ResultsThe total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enrichment analysis proved the most part of differentially expressed genes had connection with ECM-receptor interaction. The two genes lists were contrasted in PPI network, and miRNA regulation networks, The most two crucial genes were identified in our study, which may be helpful to improve Invasive ductal carcinoma treatment. Additionally, experimental results shows that the COL4A1 gene, one of identified genes, played important roles in both of proliferation and colony formation in Invasive ductal carcinoma.ConclusionsInvasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell.

Highlights

Invasive ductal carcinomas (IDC) is a very typical breast cancer [1]
Invasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell
We found that most of them were connected with cytoplasmic movement method (6/10),including Cell adhesion (20.5% Differentially expressed genes (DEGs) were enriched with p = 3.64E-10), biological adhesion (15.66%; p = 1.18E-06), skeletal system development (12.05%; p = 4.79E-06), extracellular structure organization (12.05%; p = 2.3E-05) and cell motion

Summary

Introduction

Invasive ductal carcinomas (IDC) is a very typical breast cancer [1]. How to describe ductal carcinomas into a terminological phrase is still a controversial problem as on purely anatomy because of lacking of a wideacceptable classification. IDC and some other types of breast cancer, like invasive lobular carcinomas (ILC) are generated from the terminal duct lobular unit (TDLU), and their morphologic distinction is impossible to show physiological source of lesions but the different parts in mechanisms of carcinogenesis. Both tumor types own a same statement in clinical pathological parameter as size, stage, etc [2], but researchers recognized that their pattern of advancement and further development are different which is based on new clinical data and analysis of pattern of metastasis [3, 4]. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets

Objectives

Results

Discussion

Conclusion