Abstract
As already discussed in some detail in previous articles (Gay and Holden,18 1929; Gay,2 1932), we are confronted with a working hypothesis of considerable strength and value in attempting to explain the etiology of human epidemic (lethargic) encephalitis. The hypothesis that epidemic encephalitis is due to a modified or adapted neurotropic strain of the virus of herpes simplex has in our opinion grown in persuasiveness. We do not propose to repeat in detail the evidence for or against the herpetic origin of true epidemic encephalitis. It may suffice to present in a semitabular form the main lines of evidence which we have previously discussed more fully, underlining those particular arguments on which we propose to offer further evidence in this article, and referring interested readers to our previous papers for a fuller discussion.
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