Abstract
AbstractBackgroundSubjective cognitive complaints (SCCs) may be a precursor to mild cognitive impairment (MCI) and dementia. This study aimed to examine the heritability of SCCs, and the influence of personality and mood on the relationship between SCCs and memory performance.MethodThe heritability of SCCs were examined in 306 twin pairs using structural equation modelling. Genetic, environmental, and phenotypic correlations between SCCs and memory performance, personality, and mood scores were determined.ResultSCCs were low to moderately heritable. Mood appeared to be related to SCCs by an environmental correlation, whereas memory performance was related to SCCs by a genetic correlation. SCCs had a significant amount of both genetic and environmental variances not explained by memory performance, personality, or mood.ConclusionOur results suggest that SCCs are influenced both by a person’s mood and their memory performance, and that these determinants are not mutually exclusive. Much of the genetic and environmental components to SCCs were specific to SCCs, with the specific factors yet to be determined.
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