THE HEPATOPROTECTIVE EFFECT OF POTATO AND APPLE PEELS AS ANTIOXIDANT ON INTOXICATED RATS WITH CCL4.

Abstract

Abstract The aim of this research is to evaluate potato and apple peels as a potential donor of phenolic compounds, and to study the effect of feeding dry powder of potato and apple peels, mixed with basal diet at two concentration (10,20%), on carbon tetrachloride (Ccl4) intoxicated rats for 4 weeks. Results of this study showed that potato peel has high levels of copper (0.826) ,calcium (39.2), copper (0.68) and calcium (26.03) ppm. Also the results revealed that total phenols content (as gallic acid %) in potato peel was higher than apple peel (3.2 vr 2.5) respectively. Among the test groups, total cholesterol was lowest significantly in rats group fed on 10% apple peel (125.4+ 5.3mg/dl), followed by rats fed 10% potato peel (114.6+1.32mg/dl), and rats group fed on 20% apple peel (110.3 + 1.26mg/dl), while the highest decrease was noticed in rats fed on20% potato peel (95.7+ 2.3mgdl) which differ significantly from control (+) (152.2+10.1mg/dl). Feeding of potato and apple peels at concentration of 20 % does not show any significant values in triglycerides, HDL-cholesterol and VLDL-cholesterol levels as compared to control (-) group. The results revealed that administration of Ccl4 to rats leads to significant decrease in AST, ALT, uric acid and creatinine levels in the rats groups receiving the two different concentration (10, 20%) of potato and apple peels when compared to control (+) Ccl4 group. Key words: Potato peel, Apple peel, Intoxicated rats, Antioxidant, phenolic compounds.