Abstract
The α2 agonists act through the endogenous sleep-promoting pathways to exert their sedative effect. Dexmedetomidine produces a decrease in activity of the projections of the locus ceruleus to the ventrolateral preoptic nucleus. This increases GABAergic release in the tuberomammillary nucleus, producing a decrease in histamine release in cortical and sub cortical projections. All patients underwent a thorough pre-anaesthetic checkup which included history taking, general examination, systemic examination and local neurological examination. Routine investigations like Haemogram, blood sugar, blood urea, serum creatinine, Chest X-Ray, ECG were carried out for all patients. All patients were taught about pain scale regarding VAS scale during pre-operative visit. Mean blood pressure in group D was lower compared to group P since immediately after induction upto 20 minutes after induction, which were statistically significant. There was no statistically significant difference in mean blood pressure of the patients between the two groups after 20 minutes.
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