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Abstract
Chronic, intermittent exposures to low levels of carbon monoxide (23% COHb) produce statistically significant elevations in red blood cell count, hematocrit, hemoglobin content, and reticulocyte percentage in rats. However, during ten postexposure days the elevations show significant reversibility. Because no significant change in plasma volumes appears to occur, the mild polycythemia is evidently due to increased erythropoiesis. The degree of polycythemis obtained is probably not critical in respect to increases in blood viscosity.
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