Abstract
A microscopic Potts-like one-dimensional model with many-particle interactions is developed to construct a statistical mechanical description of the melting of heterogeneous sequence duplex DNA. For this model, referred as the generalized model of polypeptide chains (GMPC), a closed-form expression for the free energy is derived. The characteristic equation of the model enables estimates on the melting temperature and transition interval, consistent with results obtained from more classical approaches. From the characteristic equation of the model, the temperature-dependent statistical weight parameter for helical states is evaluated. This parameter is shown to change throughout the transition from a harmonic form in early regions of the transition to an arithmetic form in later stages. The GMPC is extended to consider the influence of sequence heterogeneity in the melting of duplex DNA.
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