The Heart and Cannabis (THC) Cohort: Differences in Baseline Health and Behaviors by Cannabis Use

Abstract

BackgroundEvidence on the cardiovascular health effects of cannabis use is limited. We designed a prospective cohort study of older Veterans (66 to 68 years) with coronary artery disease (CAD) to understand the cardiovascular consequences of cannabis use. We describe the cohort construction, baseline characteristics, and health behaviors that were associated with smoking cannabis.ObjectiveTo understand the cardiovascular consequences of cannabis use.DesignWe designed a prospective cohort study of older Veterans (66 to 68 years) with CAD.ParticipantsA total of 1,015 current cannabis smokers and 3,270 non-cannabis smokers with CAD.Main MeasuresUsing logistic regression, we examined the association of baseline variables with smoking cannabis in the past 30 days.ResultsThe current cannabis smokers and non-current smokers were predominantly male (97.2% vs 97.1%, p=0.96). Characteristics associated with recent cannabis use in multivariable analyses included lack of a high school education (odds ratio [OR] 2.15, 95% confidence interval [CI]: 1.10 to 4.19), financial difficulty (OR 1.47, 95% CI: 1.02 to 2.11), tobacco use (OR 3.02, 95% CI: 1.66 to 5.48), current drug use (OR 2.82, 95% CI: 1.06 to 7.46), and prior drug use (OR 2.84, 95% CI: 2.11 to 3.82). In contrast, compared to individuals with 0 to 1 comorbid conditions, those with 5 chronic conditions or more (OR 0.43, 95% CI: 0.27 to 0.70) were less likely to smoke cannabis.ConclusionsIn this older high-risk cohort, smoking cannabis was associated with higher social and behavioral risk, but with fewer chronic health conditions.