Abstract
Few studies have examined the effects of N,N-dipropyltryptamine (DPT) in vivo. In these studies, DPT was tested in a drug-elicited head twitch assay and in a conditioned head twitch assay in Swiss Webster mice. The effects of DPT were challenged with the selective serotonin (5-HT) 2A antagonist M100907, the 5-HT1A selective antagonist WAY-100635, and with depletion of central 5-HT produced via the synthesis inhibitor p-chlorophenylalanine (PCPA). DPT elicited dose-dependent effects in both assays, and the shape of the dose-effect curves was biphasic. WAY-100635 produced a parallel rightward shift in the dose-effect curves, indicative of surmountable antagonism, but the antagonist effects of M100907 were functionally insurmountable. The contribution of 5-HT2A receptors, 5-HT1A receptors, and central 5-HT in the mediation of these effects will be discussed. These studies supported by USPHS grants DA020645 and RR00165, and by the College on Problems of Drug Dependence.
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