Abstract
Background Peptide YY (PYY) and neuropeptide Y (NPY) are members of the PP-fold peptide family. PYY is expressed by endocrine cells of the gut, whereas NPY occurs in enteric, sensory, cerebral and autonomic neurons. While PYY is involved in the regulation of gut function and satiety, NPY is known to contribute to the regulation of emotionalaffective behaviour, cognition, seizure activity, pain and satiety. Since we have previously found that the NPY system plays a role in the gut-brain axis, we explored in which way knockout of PYY and PYY plus NPY alters the emotional-affective behaviour in mice and how this phenotype is altered by experimental colitis.
Highlights
Peptide YY (PYY) and neuropeptide Y (NPY) are members of the PP-fold peptide family
Since we have previously found that the NPY system plays a role in the gut-brain axis, we explored in which way knockout of PYY and PYY plus NPY alters the emotional-affective behaviour in mice and how this phenotype is altered by experimental colitis
Inflammation was assessed by the colonic myeloperoxidase content, anxiety-related behaviour was evaluated with the elevated plus maze (EPM) and open field (OF) tests, and depression-like behaviour was estimated with the forced swim test (FST)
Summary
The gut-mood axis: a novel role of the gut hormone peptide YY on emotional-affective behaviour in mice. Address: 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria and 2Neurobiology Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. Published: 12 November 2009 BMC Pharmacology 2009, 9(Suppl 2):A13 doi:10.1186/1471-2210-9-S2-A13. 15th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Andrea Laslop and Thomas Griesbacher Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S2-info.pdf
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