Abstract
Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.
Highlights
Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue
*Correspondence: mark.philip.plummer@gmail.com 1Discipline of Acute Care Medicine, Level 5, Eleanor Harold Building, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000 Full list of author information is available at the end of the article
A potential confounder was that patients receiving ‘late’ EN received parenteral nutrition (PN) while awaiting EN. e authors reported no difference in the primary outcome measure, plasma GLP-1 concentrations, between the two groups but did report significant increases in T-helper and regulatory T cell numbers and a reduction in cytotoxic T cells in the patients receiving ‘early’ EN
Summary
Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective e ects. E rationale underlying this study is that enteral nutrient is a potent stimulant of glucagon-like peptide-1 (GLP-1) secretion [2], and, in animal models, pharmacological GLP-1 administration has been reported to have immune-modulating and neuroprotective properties [3,4].
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