Abstract
The subcutaneous growth of the Lewis lung tumour in C57BL mice chronically exposed to fresh cigarette smoke was increased above that in age-matched control mice. When murine sarcoma virus (Harvey) induced tumour cells were introduced to the lungs of groups of BALB/c mice, only mice chronically exposed to fresh cigarette smoke died with tumour cells in the lungs. Tumour cell growth in mice during short term cigarette smoke exposure was indistinguishable from that in controls.
Highlights
CIGARETTE smoking has been associated with an increased incidence of neoplasia in the respiratory system and elsewhere in the body (Royal College of Physicians, 1971; U.S Public Health Service, 1971)
C57BL mice were exposed to fresh cigarette smoke for 3 days, 23 weeks and 38 weeks before the subcutaneous inoculation of 106 Lewis lung tumour cells
The growth of the tumours in mice that had been exposed to fresh cigarette smoke for 23 and 38 weeks was significantly increased compared with control animals
Summary
CIGARETTE smoking has been associated with an increased incidence of neoplasia in the respiratory system and elsewhere in the body (Royal College of Physicians, 1971; U.S Public Health Service, 1971). Studies of the influence of cigarette smoke inhalation on pulmonary tumourigenesis in mice exhibiting a relatively high natural incidence of lung adenomata and adenocarcinomata showed an earlier onset and increased incidence of these neoplasms (Leuchtenberger and Leuchtenberger, 1970). The cigarette smoke product(s) could promote carcinogenesis by acting directly on malignant or premalignant cells, or by modifying some regulatory influence of the body opposing the growth of the neoplasm. We report the ability of transplantable tumours to grow in mice after short term or chronic cigarette smoke inhalation. The ability of tumours to grow subcutaneously and metastasize to the lungs, as well as the growth of cells introduced directly into the pulmonary system, have been examined
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