Abstract
An earlier study (Willis, 1935) showed that in rats the brain is a very favourable nidus for the growth of implanted embryo tissues. Following the introduction of small quantities of embryo mince, large masses of bone and cartilage, epidermal, and mucosal cysts, salivary and other glands, skeletal muscle, and teeth were obtained; and in the most successful implants the rate of growth and differentiation approximated to that of an intact animal. The perfect growth of complete teeth in these experiments suggested that it might also prove possible to grow complete bones in the same way. This hope has been realized; it has proved possible, following the intracerebral implantation of early cartilaginous primordia of the limb buds of young embryos, to obtain well-formed long bones such as femur or tibia nearly 2 cm long in the brains of the host rats. In some of the experiments two long bones with an intervening joint have developed.
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