Abstract
N-Methoxy- N-methylamide,popularly addressed as the Weinreb amide, has surfaced as an amidewith a difference. This amide has served as an excellent acylatingagent for organolithium or organomagnesium reagents and as a robustequivalent for an aldehyde group. These two aspects have been exploitedexhaustively in various synthetic endeavors. This review presentsthe growing synthetic utility of the Weinreb amide not only in academiccircles, but also its popular use on kilogram scale by various pharmaceutical industriesacross the globe. 1 Introduction 1.1 Limitations 2 Methods for Preparation 3 Applications 3.1 Use in Heterocyclic Chemistry 3.2 Use in Total Synthesis 3.3 Use in Industry on Kilogram Scale 3.4 Synthetic Equivalents and Building Blocks 4 Miscellaneous 5 Conclusion
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