The gravitostat regulates fat mass in obese male mice while leptin regulates fat mass in lean male mice

Abstract

The authors compared the effects of leptin versus weight loading using intraperitoneal weighted capsules (‘gravitostat stimulation’) on changes in fat mass in mice. Leptin infusion suppressed body weight and fat mass in lean but not in overweight or obese mice. Weight loading decreased body weight in overweight and obese mice.