Abstract
Lethally irradiated (900 rads), bone-marrow-protected rabbits were given allogeneic thymocytes intravenously. Autoradiography by means of local splenic infusion of (H3) thymidine revealed progeny of two differentiated T-cell lines. Electron microscopy confirmed these observations in detail. An analogy with cellular immunity reactions in an "isolated T-cell system", performed in draining lymph nodes after a variety of antigenic stimuli is presented. The functional properties of these T-blasts and their lymphoid descendants are discussed.
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Schedule a callMore From: Virchows Archiv. B, Cell pathology including molecular pathology
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