Abstract
The myocardial tissue pressure during diastole was measured in the inner and outer halves of the left ventricular wall of eight dogs with open chests and mean left ventricular end-diastolic pressure of 2.3 mm Hg. The myocardial tissue pressures were measured by the flow-cessation technique and modified needle-vein sensors with an accuracy of 0.7 mm Hg (SD 1.0). The lowest tissue pressure in the outer half of the left ventricular wall during diastole was over twice as high, 12.0 mm Hg (SD 2.0), as that in the inner half, 5.6 mm Hg (SD 1.7) ( P < 0.001). Within the myocardial wall, the lowest pressure occurs at the end of diastole rather than at the beginning as in the ventricular lumen. Thus, there is a gradient in myocardial wall tissue pressure in diastole, which is in the reverse direction of that present during systole. The presence of this gradient offers a simple explanation of the preferential flow to the inner layers of the left ventricle during diastole.
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