Abstract
Cancer Tumor growth is enhanced by some members of the ceramide family of lipids and the enzymes that produce them. However, Gencer et al. found that C18-20 ceramides synthesized by the enzyme CerS4 acted as tumor suppressors. The ceramides prevented a transforming growth factor–β (TGF-β) receptor complex from activating the Shh pathway. CerS4 inhibited metastases from mammary tumors and the development of the hairloss disorder alopecia in mice. The TGF-β and Shh pathways are challenging to target pharmacologically; these findings suggest that some ceramides may have therapeutic potential against these pathways in various disorders. Sci. Signal. 10 , eaam7464 (2017).
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