Abstract
The golden hours of septic shock?
Highlights
Goal directed haemodynamic optimisation has been demonstrated to increase mortality when initiated on the intensive care unit (ICU)
A reduced hospital mortality was found in the treatment of severe sepsis, from 46.5% with standard treatment to 30.5% with early goal directed therapy
This study demonstrates that increased administration of fluids and more controversially blood can reduce mortality when administered early
Summary
Goal directed haemodynamic optimisation has been demonstrated to increase mortality when initiated on the intensive care unit (ICU). This study is original as it recruits patients early, in the hospital emergency department before admission to the ICU. It uses central venous saturation as the resuscitation end point
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