The gold standard EUS FNA false positive and false suspicious rates: correlation with surgical pathology in the absence of neoadjuvant therapy (Mayo Clinic 1993-2007 experience)

Abstract

Background: It is generally assumed that the false positive [FP] rate for EUS FNA is 0-1% and a positive interpretation is regarded as confirmation of malignancy. However, the FP rate for FNA obtained via other routes is reported to be 1-16% and even greater. We hypothesized that the FP and false suspicious [FS] rates for EUS FNA are greater than currently perceived and sought to determine the etiology of the false cytological interpretations.