Abstract
Although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently. Some of them, alone or in combination, can be used in humans, without further clinical trials.
Highlights
“ we do not know everything about aging, we know enough to start its pharmacologic suppression using clinically approved drugs.”
The proposal was based on hyperfunction theory that aging is a continuation of development, driven in part by growth-promoting pathways, such as mTOR [2]
Standard medical interventions can prolong lifespan without extending healthspan but anti-aging interventions increase lifespan by slowing aging and delaying age-related diseases
Summary
“ we do not know everything about aging, we know enough to start its pharmacologic suppression using clinically approved drugs.” Published in 2010, these opening words of the paper entitled “Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal” are still relevant today [1]. We just need clinically available inhibitors (drugs) of these signaling pathways to extend both healthspan and lifespan, by slowing aging. Treatment of non-limiting deteriorations with “healthspan” drugs may extend lifespan, when lifelimiting aging is sufficiently decelerated and an animal (or human) lives long enough to die from this deterioration.
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