Abstract
The inner layer of the glomerular capillary basement membrane extends across the inner portion of endothelial fenestrations and is continuous with the surface coat material beneath endothelial cytoplasm. It is in a position to account for the filtration barrier to plasma albumin observed by Ryan and Karnovsky [ Fed. Proc. 34 , 877 (1975); Kidney Int. 9 , 36 (1976)] with normal blood flow. Different parts of the glomerular capillary wall can act as barriers to other tracers studied under different conditions by various investigators.
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