Abstract
BackgroundA glomus tumor is a rare neoplasm usually found in the dermis or subcutaneous tissue of the extremities. It is rare for the glomus tumor to occur on the head and face. Only 26 glomus tumors of the oral region and affected bone have been reported in the English-language literature (Table 1). We report a case of a glomus tumor at the mandible. As a new point, the glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible.Case presentationThe patient was a 44-year-old Japanese man who complained swelling of the right mandible. Radiographic examination showed a multilocular radiolucency area in the left mandible. Radiographic findings on our case resembled those of a common benign tumor. The lesion occupied to the premolar and molar area and revealed that the tumor resorbed the roots of the teeth. The lesion was removed surgically with the buccal cortical bone and buccal mucosa in contact with the mass of the tumor. The mass fully excised intraorally under general anesthesia, and the inferior alveolar nerve in contact with the mass was preserved.The specimen was pathologically diagnosed as a glomus tumor. Immunohistochemical staining was positive for vimentin, muscle-specific actin/HHF35, and calponin. A hairline-shaped area of positive staining for type IV collagen surrounding the tumor cells was also observed. In contrast, staining for alpha-SMA, cytokeratin (AE1/AE3), cytokeratin (CAM5.2), CK19, CD31, CD34, CD68, p63, S-100, Factor VIII, and desmin was all negative. The Ki-67 labeling index was almost 1%.A recurrent tumor was again detected in the site below the primary tumor at an 8-year follow-up, and it was surgically removed. The patient has had no symptoms of recurrence in 2 years after the second operation.ConclusionThe glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. The immunohistochemical features of the tumor were consistent with those described in previous reports. It is important to completely remove the Glomus tumor.
Highlights
A glomus tumor is a rare neoplasm usually found in the dermis or subcutaneous tissue of the extremities
The glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible
We present a case of a glomus tumor of the mandible
Summary
The glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. The glomus tumor recurred at 8 years later in this case. Authors’ contributions KK conceived this report, drafted the article and revising it critically for important intellectual content. Ethics approval and consent to participate The presented case report is in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent for publication Informed consent for publication of this article and its contents was obtained from the patient. Author details 1Department of Oral and Maxillofacial Surgery, Graduate School, Mie University, 174, Edobashi 2-chome, Tsu-shi, Mie 514-8507, Japan. Author details 1Department of Oral and Maxillofacial Surgery, Graduate School, Mie University, 174, Edobashi 2-chome, Tsu-shi, Mie 514-8507, Japan. 2Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan. 3Department of Oral Pathology, Division of Oral Health Sciences, Graduate school of Tokyo Medical and Dental University, Tokyo, Japan
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