The glomerular filtration rate, effective renal plasma flow, and renal blood flow in the adult male chacma baboon (Papio ursinus).

Abstract

The radionuclide determination of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) has been validated in man, but not in the primate. GFR, ERPF, and renal blood flow (RBF) were measured in a group of 12 adult male chacma baboons using radiopharmaceuticals. GFR was determined using 99mtechnetium-labelled diethylenetriamine-pentacetic acid. ERPF was measured with 131iodine-labelled hippuran. RBF, body surface area, and kidney weights were calculated using standard formulae. GFR was 49 +/- 11 ml/min and ERPF was 237.9 +/- 54.2 ml/min. Calculated RBF was 430.7 +/- 111.9 ml/min and 507.4 +/- 138.4 ml/min/100 g of renal tissue. The results are in agreement with those obtained using more laborious nonradioisotopic techniques such as para-aminohippurate (PAH) and creatinine clearance and could serve as baseline normal values in the adult male chacma baboon.