The Glomerular Filtration Rate and Metabolic Syndrome Among High-tech Workers in Southern Taiwan

Abstract

PP-30-200 Background/Aims: Metabolic syndrome is highly correlated with cardiovascular diseases. In previous studies, the prevalence of metabolic syndrome was found to be elevated among shift workers, and some studies found that a lower glomerular filtration rate (GFR) was related to cardiovascular diseases. Therefore, we conducted a study to evaluate whether GFR is associated with metabolic syndrome among workers in the high-tech industry. Methods: We recruited workers working in an industrial park in southern Taiwan during their routine annual health examination between 1st July and 31st August, 2009. Participants accept blood sampling and received anthropometric measurements. The GFR was categorized using the Modification of Diet in Renal Disease system. Results: A total of 15,750 workers participated in this study, and the prevalence rate of metabolic syndrome was 3.1%. We observed positive associations between metabolic syndrome and gender, age, BMI, cholesterol, GOT, GPT, uric acid and GFR (all with P < 0.05). On further analyses using logistic regressions, we found BMI, cholesterol, GOT, GPT, uric acid, and GFR were predictors of metabolic syndrome. After adjusting for other factors, we found cholesterol (adjusted odds ratio [AOR] = 2.35, 95% confidence interval [CI]: 1.82–3.05), GOT (AOR = 1.91, 95% CI: 1.43–2.56), GPT (AOR = 1.91, 95% CI: 1.51–2.43), uric acid (AOR = 1.64, 95% CI: 1.31–2.05), and GFR (chronic kidney disease [CKD]-1 AOR = 5.29, 95% CI: 2.96–9.47; CKD-2 AOR = 3.47, 95% CI: 1.99–6.05; CKD-4 AOR = 199.57, 95% CI: 2.59–15325.33), were independent predictors of metabolic syndrome. Conclusion: In the high-tech industry, metabolic syndrome is associated with cholesterol, GOT, GPT, uric acid, and GFR. As renal function may increase the risk of metabolic syndrome and thus cause cardiovascular disease, early detection of renal function impairment may facilitate the prevention of further damages to the cardiovascular system.